An Experimental New Therapy Could Halt Type-1 Diabetes

Insulin injection

Importantly, all eight subjects in the placebo arm needed to increase their insulin doses over the 12-month course of the study, whereas individuals receiving the new treatment all remained stable.

The report of the early-stage clinical trial, published Wednesday in the journal Science Translational Medicine, offers some preliminary reassurance that immunotherapy could be used safely in this growing population.

Speaking on the topic, Dr. Peakman said, "Type 1 diabetes comes about when the immune system inadvertently and irreparably damages beta cells that make insulin ..." In the current study, injections of an immunotherapeutic agent caused no detectable worrisome response - not even redness or swelling at the site of injection - prompting the authors to declare its safety profile "very favorable".

AMG National Trust Bank Increases Position in General Electric Company (NYSE:GE)
Market Capitalization can be thought of as the overall price to buy the company. (NYSE:CNK) on Monday, October 31 to "Buy" rating. It is negative, as 68 investors sold GE shares while 818 reduced holdings. 116 funds opened positions while 609 raised stakes.

The immunotherapy literally re-educates the body's immune system, and teaches the cells that they should not attack the beta cells. The approach, called antigen-specific immunotherapy, has seen growing success in the treatment of allergies to common foods, such as peanuts, eggs and soy.

There is now no cure for type 1 diabetes, which can affect major organs in the body, including the heart, blood vessels, nerves, eyes and kidneys. What's more, researchers have been hesitant to implement newer clinical strategies like immunotherapies - molecules created to stave off destructive immune responses in diabetes by mimicking a portion of proinsulin peptide - due to concerns of inadvertently aggravating the disease.

There may be the potential to "retrain" the immune system to slow the progression of type 1 diabetes, according to results of a new clinical trial.

Gorka: North Korea Isn't Rex Tillerson's Business
That is his mandate. "I said for reporters to force our chief diplomat, the wonderful Rex Tillerson , to give details of military options is nonsensical ", Gorka said.

Here, researchers used a proinsulin peptide fragment-a snippet of the precursor form of insulin. Patients were randomized into one of three groups: one group received immunotherapy every two weeks; a second group received immunotherapy every four weeks; and a third group received placebo. The subjects' glycemic control and insulin use were then tracked for another six months.

"That would mean people at risk of type 1 diabetes might one day need to take less insulin, and perhaps see a future where no one would ever face daily injections to stay alive". Twenty-seven people with early-stage type 1 diabetes were randomly assigned to receive the placebo or the proinsulin peptide immunotherapy. Thus the immune cells attack this imposter and leave the insulin secreted intact. Furthermore, the patients demonstrated signs of increased regulatory immune responses, and decreased activation of beta cell-attacking T cells. Type 1 diabetes is now considered to be incurable.

Toilet - Ek Prem Katha: Film unmissable, says first review
Here are some more tweets that are a proof that the dry spell of box office is soon going to end with Toilet: Ek Prem Katha . Enter Vasundhara (Kajol), who is Raghuvaran's boss and wants to dictate the terms of Raghuvaran's services.

Related news:

Hot News

isis-killer-beheading-video-story-top Karolina Pliskova passes in the quarter-finals
Aug 11, 2017 - 08:22
Muguruza will next play Australian qualifier Ashleigh Barty, who upset 16th-seeded Elena Vesnina 6-3, 5-7, 6-4 to advance. But the Japanese rallied to match the lanky Czech shot-for-shot in a gripping second set, then dominated the tiebreak.

isis-killer-beheading-video-story-top Mertz: Is it time to investigate Trump's investigation?
Aug 11, 2017 - 08:15
Reports surfaced last week that Mueller had impaneled a grand jury in Washington . We have an investigation of something that never took place.

isis-killer-beheading-video-story-top Donald Trump warns North Korea, says 'fire and fury' not tough enough
Aug 11, 2017 - 08:14
The missiles would fly over Japan and land in the waters off the USA territory of Guam if dictator Kim Jong Un gave approval. With nearly 1.2 million people now serving in the military, North Korea also has the world's fourth largest army.

isis-killer-beheading-video-story-top Man drinks beer full of dead geckos
Aug 11, 2017 - 07:54
A Fountain Valley man is suing Heineken and The Kroger Co ., saying he found these two dead leopard geckos in his beer. The suit, which seeks unspecified damages, also names The Kroger Co., which owns the Ralphs grocery chain.

isis-killer-beheading-video-story-top Trump to North Korea: Be very, very nervous
Aug 11, 2017 - 07:53
Lee Jin-woo told reporters that Seoul also believes the North has made "considerable" progress in miniaturizing nuclear warheads. Last April, Senator John McCain said that North Korea is presenting the U.S. with a "Cuban Missile Crisis in slow motion".

isis-killer-beheading-video-story-top BBCI: China transport: Deadly coach crash in road tunnel
Aug 11, 2017 - 07:52
At least 36 people were killed and 13 injured after a coach crashed in a road tunnel in northern China, state media reported. The bus was travelling to Luoyang city in Henan province from Chengdu city, the capital of Sichuan province in he southwest.

Teekay LNG Partners LP (TGP) Lowered to Buy at ValuEngine
Aug 11, 2017 - 07:49
HITE Hedge Asset Management LLC boosted its position in shares of Teekay Offshore Partners L.P.by 32.1% in the fourth quarter. Finally, Evergreen Capital Management LLC bought a new position in GasLog Partners during the first quarter worth $1,215,000.

isis-killer-beheading-video-story-top Amazon's United Kingdom corporation tax halves while turnover rises 54%
Aug 11, 2017 - 07:48
Amazon UK's corporation tax bill halved to £7.4m a year ago despite the internet giant's retail sales soaring past £7bn. The company has said it meets all tax obligations in the United Kingdom and every other country in which it operates.

isis-killer-beheading-video-story-top Venezuela's high court removes fifth opposition mayor
Aug 11, 2017 - 07:37
Opposition leaders and governments around the world have decried the assembly's creation as the consolidation of a dictatorship. Last Friday the Constituent Assembly was sworn in with the rejection of a large part of the global community.

isis-killer-beheading-video-story-top BMC makes singing of Vande Mataram a must in its schools
Aug 11, 2017 - 07:35
The Brihanmumbai Municipal Corporation (BMC) today cleared a proposal making singing of Vande Mataram mandatory in civic schools. Congress leader in BMC Ravi Raja said in a democracy one can not make it compulsory for a person to sing the Vande Mataram.

isis-killer-beheading-video-story-top Modern slavery more prevalent than thought — United Kingdom crime agency
Aug 11, 2017 - 07:26
In response the NCA begins a new campaign focused on sexual and labour exploitation, explaining how the public can help stop it. A Romanian gang who were operating across Europe had made five million euros (US$5.8 million) from trafficking and slavery.

isis-killer-beheading-video-story-top Masterful Nadal rolls past Coric in Montreal
Aug 11, 2017 - 07:25
Federer will now face Spain's David Ferrer after he won a three set match against the United States' Jack Sock 7-6, 3-6, 6-1. Seventh-seeded Bulgarian Grigor Dimitov topped Mischa Zverev 6-3, 3-6, 6-3.

isis-killer-beheading-video-story-top South African freed by al-Qaida speaks out
Aug 11, 2017 - 07:19
Stephen McGown was snatched from Timbuktu in 2011 by Mali-based Islamist extremists who have made a fortune by demanding ransoms. The South African tourist - now fully bearded, says he will keep his beard which he observed had become fashionable.

isis-killer-beheading-video-story-top Chelsea's predicted 3-4-2-1 for Premier League opener vs Burnley
Aug 11, 2017 - 06:59
That stance is sure to infuriate Conte, who is reportedly unhappy at the club's lack of activity in the market. Chelsea have sold midfielder Nemanja Matic to Manchester United and Diego Costa is also poised to leave.

isis-killer-beheading-video-story-top Packers open preseason against Eagles
Aug 11, 2017 - 06:57
Looking back on his own slow start previous year , Nelson pointed to the limited work he got in training camp as the culprit. But his favorite player was Brett Favre, who played for the Packers from the time Wentz was born to past his 15th birthday.